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Re: On herceptin/dmi trial
Irene,
It sure does seem like more than coincidence that your bili shot up after the surgery. Obviously everyone wants you to have a healthy liver - and you make a good point about "moving on" to another med or progression not helping with that at all.
I forget, are you still on a 3 week regimen or 4 weeks?
Is your onc concerned about your your well being due to the bili? Seems like it is improving, slowly. I don't know what "grade" that level would be considered. On balance, does she feel continuing on the DM1 would be in your best interests? If so, having her contact Genentech could be helpful.
Interesting that your other liver functions are so good - I'm the opposite with bili within normal and everything else out of range.
On the liver cleanse, you say "they" don't want you doing anything - who is "they"? I would think that somewhat normal dietary interventions as have been suggested here and before would be ok. And of course may or may not help...
Hang in there my friend, keep us posted
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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