HER2 Support Group Forums - View Single Post - more on risks associated with G-CSF and GM-CSF which support White blood cells wchemo

Rich66 · 07-18-2009, 06:59 PM

I found this provoking from the original study Lani posted:
"It is unclear if the growth factors cause an increased risk or if the requirements for their use cause an increased risk"

Now..does the more recent abstract mean the scale has been tipped towards even using CSFs prophylactically in some cases?
"Meta analysis from randomized trials shows that granulocyte colony-stimulating factor prophylaxis is associated with patients receiving more intensive chemotherapy, having better survival, but also having a higher risk of secondary acute myeloid leukemia."

It doesn't say whether they analyzed adjuvant, metastatic or both settings.
I'd love to see the full text...when it comes out.

07-18-2009, 06:59 PM	#7
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	I found this provoking from the original study Lani posted: "It is unclear if the growth factors cause an increased risk or if the requirements for their use cause an increased risk" Now..does the more recent abstract mean the scale has been tipped towards even using CSFs prophylactically in some cases? "Meta analysis from randomized trials shows that granulocyte colony-stimulating factor prophylaxis is associated with patients receiving more intensive chemotherapy, having better survival, but also having a higher risk of secondary acute myeloid leukemia." It doesn't say whether they analyzed adjuvant, metastatic or both settings. I'd love to see the full text...when it comes out.