HER2 Support Group Forums - View Single Post - The traditional diet of Greece and cancer.

R.B. · 06-28-2009, 08:06 AM

More of the same. (-:

Profound is a word I like (-:

PGE 2 is a direct downstream product of Omega 6, and as above, increases HER2 expression.

PGE 2 is also connected with inflammation and the growth of new cells and blood vessels. If you eat less Omega 6, and reduce your intake below 4%, balance the plant based Omega 3 and 6 fats and get a gram or two of long chain Omega 3 DHA and EPA you will reduce your cancer risk profile.

Nobody makes any money out of telling you to eat LESS Omega 6, in fact the drugs companies would make a lot less, the food producers would have to reformulate most processed foods, margarine producers would be out of a job, and farmers would have to switch to other crops.

You cannot generally sell a negative diet recommendation that has no product attached. It is human nature industry will not be out there marketing eat less Omega 6, because it does not attract advertising budgets, or column inches in a world that takes comfort from being part of the pack. Those with the biggest financial interests would in the short term be shooting themselves in the foot.

In the long term they would be helping to create a healthier happier world and a more secure future for the species, but hey where does that appear on the big company corporate balance sheet, or in the way we value each other.

http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential.
Spencer L, Mann C, Metcalfe M, Webb M, Pollard C, Spencer D, Berry D, Steward W, Dennison A.

Department of HPB and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, United Kingdom.

Omega-3 fatty acid (omega-3 FA) consumption has long been associated with a lower incidence of colon, breast and prostate cancers in many human populations. Human trials have demonstrated omega-3 FA to have profound anti-inflammatory effects in those with cancer. In vitro and small animal studies have yielded a strong body of evidence establishing omega-3 FA as having anti-inflammatory, anti-apoptotic, anti-proliferative and anti-angiogenic effects. This review explores the evidence and the mechanisms by which omega-3 FA may act as angiogenesis inhibitors and identifies opportunities for original research trialling omega-3 FAs as anti-cancer agents in humans. The conclusions drawn from this review suggest that omega-3 FAs in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found principally in oily fish have potent anti-angiogenic effects inhibiting production of many important angiogenic mediators namely; Vascular Endothelial Growth Factor (VEGF), Platelet-Derived Growth Factor (PDGF), Platelet-Derived Endothelial Cell Growth Factor (PDECGF), cyclo-oxygenase 2 (COX-2), prostaglandin-E2 (PGE2), nitric oxide, Nuclear Factor Kappa Beta (NFKB), matrix metalloproteinases and beta-catenin.

06-28-2009, 08:06 AM	#296
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	More of the same. (-: Profound is a word I like (-: PGE 2 is a direct downstream product of Omega 6, and as above, increases HER2 expression. PGE 2 is also connected with inflammation and the growth of new cells and blood vessels. If you eat less Omega 6, and reduce your intake below 4%, balance the plant based Omega 3 and 6 fats and get a gram or two of long chain Omega 3 DHA and EPA you will reduce your cancer risk profile. Nobody makes any money out of telling you to eat LESS Omega 6, in fact the drugs companies would make a lot less, the food producers would have to reformulate most processed foods, margarine producers would be out of a job, and farmers would have to switch to other crops. You cannot generally sell a negative diet recommendation that has no product attached. It is human nature industry will not be out there marketing eat less Omega 6, because it does not attract advertising budgets, or column inches in a world that takes comfort from being part of the pack. Those with the biggest financial interests would in the short term be shooting themselves in the foot. In the long term they would be helping to create a healthier happier world and a more secure future for the species, but hey where does that appear on the big company corporate balance sheet, or in the way we value each other. http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential. Spencer L, Mann C, Metcalfe M, Webb M, Pollard C, Spencer D, Berry D, Steward W, Dennison A. Department of HPB and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, United Kingdom. Omega-3 fatty acid (omega-3 FA) consumption has long been associated with a lower incidence of colon, breast and prostate cancers in many human populations. Human trials have demonstrated omega-3 FA to have profound anti-inflammatory effects in those with cancer. In vitro and small animal studies have yielded a strong body of evidence establishing omega-3 FA as having anti-inflammatory, anti-apoptotic, anti-proliferative and anti-angiogenic effects. This review explores the evidence and the mechanisms by which omega-3 FA may act as angiogenesis inhibitors and identifies opportunities for original research trialling omega-3 FAs as anti-cancer agents in humans. The conclusions drawn from this review suggest that omega-3 FAs in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found principally in oily fish have potent anti-angiogenic effects inhibiting production of many important angiogenic mediators namely; Vascular Endothelial Growth Factor (VEGF), Platelet-Derived Growth Factor (PDGF), Platelet-Derived Endothelial Cell Growth Factor (PDECGF), cyclo-oxygenase 2 (COX-2), prostaglandin-E2 (PGE2), nitric oxide, Nuclear Factor Kappa Beta (NFKB), matrix metalloproteinases and beta-catenin. Last edited by R.B.; 06-28-2009 at 08:09 AM..