HER2 Support Group Forums - View Single Post - Zyflamend - Cox 2 Herbal Suppresses Prostate Cancer Growth

Rich66 · 05-25-2009, 01:00 PM

How It Works

Bottom Line: Laboratory studies suggest Zyflamend may have anti-inflammatory and anticancer activities. But clinical evidence is lacking.

Zyflamend is a herbal supplement consisting of Holy basil, turmeric, ginger, green tea, rosemary, hu zhang, Chinese goldthread, barberry, oregano, and scullcap. Promoters of Zyflamend claim that it has anti-inflammatory and antiaging effects. It has been shown in one laboratory study to reduce inflammation and cause cell death, but human data is lacking.
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Purported Uses

Cancer treatment
One laboratory showed that Zyflamend can reduce the number of prostate cancer cells in the laboratory. Data from clinical trials are lacking. Inflammation
A lab study showed that Zyflamend reduces inflammation but there are no data from clinical trials.
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Research Evidence

One laboratory study showed that Zyflamend reduced the number of prostate cancer cells by inactivating the COX-2 enzyme activity and by inducing cell death.
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Warnings

The FDA has recently issued a letter to an Internet distributor for exaggerated claims made for Zyflamend. Individuals taking Zyflamend should inform their physicians.
Women who are pregnant or nursing should consult their physicians before using Zyflamend.

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Do Not Take If

If you have hypersensitivity to any of the constituents.
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Clinical Summary

Zyflamend is an herbal extract of ten different herbs ⁽¹⁾. It is promoted as having anti-inflammatory and antiaging properties. Supporters claim that the beneficial effects of Zyflamend are due to the constituents, many of which reduce inflammation by decreasing cyclooxygenase-2 (COX-2) activity. In vitro studies showed that Zyflamend inhibits COX-1 and COX-2 enzymes, induces apoptosis ⁽⁴⁾, and inhibits proliferation ⁽⁸⁾ of human prostate cancer cells. Zyflamend is being investigated in a Phase I clinical trial involving men with prostatic intraepithelial neoplasia (PIN) ⁽²⁾ ⁽⁷⁾.

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Purported uses

Antiaging
Cancer treatment
Inflammation

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Constituents

Ocimum sanctum (Holy basil) leaf
Curcuma longa (Turmeric) rhizome
Zingiber officinale (Ginger) rhizome
Camellia sinensis (Green tea) leaf
Rosemarinus officinalis (Rosemary) leaf and essential oil
Polygonum cuspidatum (Hu Zhang) root
Coptis chinensis (Chinese goldthread) root
Berberis vulgaris (Barberry) root
Origanum heracleoticum (Oregano) leaf
Scutellaria baicalensis (Scullcap) root
⁽¹⁾
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Mechanism of Action

Holy basil, turmeric, ginger, green tea, rosemary, hu zhang, Chinese gold thread and Scutellaria inhibit cyclooxygenase-2 activity and thereby reduce inflammation. In an in vitro study, Zyflamend reduced the proliferation of prostate cancer cells by inhibiting COX-2 activity and by inducing apoptosis ⁽²⁾. Zyflamend down-regulates NF-kappa B activiation ⁽⁶⁾. Zyflamend has been shown to inhibit Leukotriene B4 formation in an animal carcinogenesis model ⁽⁵⁾.

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Warnings

The FDA has recently issued a letter to an Internet distributor for exaggerated claims made for Zyflamend ⁽³⁾. Individuals using Zyflamend should be cautious of such claims.
Women who are pregnant or nursing should consult their physicians before using Zyflamend.
top

Contraindications

Hypersensitivity to any of the constituents.
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Herb-Drug Interactions

The herbal constituents of Zyflamend can potentially interact with other drugs. Please check the individual herb listed above for more information.

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Literature Summary and Critique

Zyflamend is currently being studied in a Phase I clinical trial involving men with prostatic intraepithelial neoplasia (PIN).
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References

Product web site. http://www.new-chapter.com (accessed on August 1, 2008).
Capodice JL, et al. ZyflamendTM, a unique preparation inhibits arachidonic acid metabolism and suppresses prostate cancer cells, in vitro. Abstract presented at the 1st International Conference of the Society for Integrative Oncology, Nov 18, 2004.
Letter from the Food and Drug Administration. http://www.fda.gov/cder/warn/cyber/2005/CL122e.pdf (accessed on August 1, 2008).
Bemis DL, et al. Zyflamend, a unique herbal preparation with non selective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression. Nutrition and Cancer 2005; 52(2): 202-12.
Yang P, Sun Z, Chan D, et al. Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model. Carcinogenesis. 2008 Nov;29(11):2182-9.
Sandur SK, Ahn KS, Ichikawa H, et al. Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products. Nutr Cancer. 2007;57(1):78-87.
Rafailov S, Cammack S, Stone BA, et al. The role of Zyflamend, an herbal anti-inflammatory, as a potential chemopreventive agent against prostate cancer: a case report. Integr Cancer Ther. 2007 Mar;6(1):74-6.
Yang P, Cartwright C, Chan D, et al. Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation. Cancer Biol Ther. 2007 Feb;6(2):228-36.

05-25-2009, 01:00 PM	#3
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Clinical Summary Purported uses Constituents Mechanism of Action Warnings Contraindications Herb-Drug Interactions Literature Summary and Critique References How It Works Bottom Line: Laboratory studies suggest Zyflamend may have anti-inflammatory and anticancer activities. But clinical evidence is lacking. Zyflamend is a herbal supplement consisting of Holy basil, turmeric, ginger, green tea, rosemary, hu zhang, Chinese goldthread, barberry, oregano, and scullcap. Promoters of Zyflamend claim that it has anti-inflammatory and antiaging effects. It has been shown in one laboratory study to reduce inflammation and cause cell death, but human data is lacking. top Purported Uses Cancer treatment One laboratory showed that Zyflamend can reduce the number of prostate cancer cells in the laboratory. Data from clinical trials are lacking. Inflammation A lab study showed that Zyflamend reduces inflammation but there are no data from clinical trials. top Research Evidence One laboratory study showed that Zyflamend reduced the number of prostate cancer cells by inactivating the COX-2 enzyme activity and by inducing cell death. top Warnings The FDA has recently issued a letter to an Internet distributor for exaggerated claims made for Zyflamend. Individuals taking Zyflamend should inform their physicians. Women who are pregnant or nursing should consult their physicians before using Zyflamend. top Do Not Take If If you have hypersensitivity to any of the constituents. top Clinical Summary Zyflamend is an herbal extract of ten different herbs ⁽¹⁾. It is promoted as having anti-inflammatory and antiaging properties. Supporters claim that the beneficial effects of Zyflamend are due to the constituents, many of which reduce inflammation by decreasing cyclooxygenase-2 (COX-2) activity. In vitro studies showed that Zyflamend inhibits COX-1 and COX-2 enzymes, induces apoptosis ⁽⁴⁾, and inhibits proliferation ⁽⁸⁾ of human prostate cancer cells. Zyflamend is being investigated in a Phase I clinical trial involving men with prostatic intraepithelial neoplasia (PIN) ⁽²⁾ ⁽⁷⁾. top Purported uses Antiaging Cancer treatment Inflammation top Constituents Ocimum sanctum (Holy basil) leaf Curcuma longa (Turmeric) rhizome Zingiber officinale (Ginger) rhizome Camellia sinensis (Green tea) leaf Rosemarinus officinalis (Rosemary) leaf and essential oil Polygonum cuspidatum (Hu Zhang) root Coptis chinensis (Chinese goldthread) root Berberis vulgaris (Barberry) root Origanum heracleoticum (Oregano) leaf Scutellaria baicalensis (Scullcap) root ⁽¹⁾ top Mechanism of Action Holy basil, turmeric, ginger, green tea, rosemary, hu zhang, Chinese gold thread and Scutellaria inhibit cyclooxygenase-2 activity and thereby reduce inflammation. In an in vitro study, Zyflamend reduced the proliferation of prostate cancer cells by inhibiting COX-2 activity and by inducing apoptosis ⁽²⁾. Zyflamend down-regulates NF-kappa B activiation ⁽⁶⁾. Zyflamend has been shown to inhibit Leukotriene B4 formation in an animal carcinogenesis model ⁽⁵⁾. top Warnings The FDA has recently issued a letter to an Internet distributor for exaggerated claims made for Zyflamend ⁽³⁾. Individuals using Zyflamend should be cautious of such claims. Women who are pregnant or nursing should consult their physicians before using Zyflamend. top Contraindications Hypersensitivity to any of the constituents. top Herb-Drug Interactions The herbal constituents of Zyflamend can potentially interact with other drugs. Please check the individual herb listed above for more information. top Literature Summary and Critique Zyflamend is currently being studied in a Phase I clinical trial involving men with prostatic intraepithelial neoplasia (PIN). top References Product web site. http://www.new-chapter.com (accessed on August 1, 2008). Capodice JL, et al. ZyflamendTM, a unique preparation inhibits arachidonic acid metabolism and suppresses prostate cancer cells, in vitro. Abstract presented at the 1st International Conference of the Society for Integrative Oncology, Nov 18, 2004. Letter from the Food and Drug Administration. http://www.fda.gov/cder/warn/cyber/2005/CL122e.pdf (accessed on August 1, 2008). Bemis DL, et al. Zyflamend, a unique herbal preparation with non selective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression. Nutrition and Cancer 2005; 52(2): 202-12. Yang P, Sun Z, Chan D, et al. Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model. Carcinogenesis. 2008 Nov;29(11):2182-9. Sandur SK, Ahn KS, Ichikawa H, et al. Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products. Nutr Cancer. 2007;57(1):78-87. Rafailov S, Cammack S, Stone BA, et al. The role of Zyflamend, an herbal anti-inflammatory, as a potential chemopreventive agent against prostate cancer: a case report. Integr Cancer Ther. 2007 Mar;6(1):74-6. Yang P, Cartwright C, Chan D, et al. Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation. Cancer Biol Ther. 2007 Feb;6(2):228-36.