Another article outlining why Omega 3 reduces the risk of BC and other cancers.
Please note the action on the Omega 6 COX2 pathways, which is what COX blocking drugs interrupt. Eating less Omega 6 and more long chain Omega 3 will reduce COX 2 activity.
Anticancer actions of omega-3 fatty acids--current state and future perspectives.
Wendel M, Heller AR.
Department of Physiology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany.
MartinaWendel@gmx.de
Omega-3 fatty acids (omega3-FA) were shown to
attenuate growth and induce apoptosis in a variety of human cancer cell lines derived from colonic, pancreatic, prostate, and breast cancer. In addition, recent findings indicate that omega3-FA
act synergistically with chemotherapeutic agents and may also be used to enhance tumour radiosensitivity. The mechanisms underlying the anti-tumour effects of omega3-FA are complex. Incorporation of omega3-FA in biological membranes alters the profile of lipid mediators generated during inflammatory reactions. Furthermore, omega3-FA act as ligands of nuclear peroxisome proliferator-activated receptors that attenuate transcription of NF-kappaB-dependent genes.
Thereby, the cyclooxygenase-2/prostaglandin E(2)-dependent production of pro-angiogenic vascular endothelial growth factor and levels of anti-apoptotic bcl-2 and bcl-X(L) are decreased. Eicosanoid-independent pro-apoptotic pathways include enhanced lipid peroxidation, modulation of mitochondrial calcium homeostasis and enhanced production of reactive oxygen species as well as activation of p53. This review article will give a comprehensive overview over the pleiotropic actions of omega3-FA and will discuss the potential of omega3-FA and derivatives like conjugated eicosapentaenoic acid as important nutritional adjuvant therapeutics in the management of various human cancer diseases and the impact of nutritional omega-3 FA on cancer prevention.