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Joan M · 05-20-2009, 08:53 PM

Terry,

I believe that the normal range for muga scores is 50-70, and my onc told me that if a muga score drops 10%, even if it's not below 50, that Herceptin should be stopped until the muga goes back up. Apparently, that's the guideline.

When I took neoadjuvant Herceptin my score always stayed in the low to mid 60s, but since my bc advanced, the score hasn't been stable. My onc took me off last fall for three months when my score went from 70 to 57.

Lately, I've been getting echos to try to eliminate another invasive procedure like the muga. The echos are not as accurate.

Joan

05-20-2009, 08:53 PM	#10
Joan M Senior Member Join Date: Oct 2007 Posts: 1,851	Terry, I believe that the normal range for muga scores is 50-70, and my onc told me that if a muga score drops 10%, even if it's not below 50, that Herceptin should be stopped until the muga goes back up. Apparently, that's the guideline. When I took neoadjuvant Herceptin my score always stayed in the low to mid 60s, but since my bc advanced, the score hasn't been stable. My onc took me off last fall for three months when my score went from 70 to 57. Lately, I've been getting echos to try to eliminate another invasive procedure like the muga. The echos are not as accurate. Joan __________________ Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!