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found this in a powerpoint presentation. Note higher loading dose (weekly is 4mg/kg, then 2 mg/kg):
Pharmacokinetic data for Herceptin® support the use of a 3-weekly dosing regimen
lTo maintain drug exposure at levels similar to those observed with the weekly regimen, Herceptin® must be administered at 8mg/kg followed by 6mg/kg 3-weekly
lThe 3-weekly regimen has been shown to be well tolerated and effective in combination with paclitaxel and alone
lThe 3-weekly regimen is being used in major trials investigating Herceptin® as adjuvant therapy
lLoading schedules will be investigated to determine whether Herceptin® steady-state levels can be attained more rapidly while maintaining safety
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