[chrisy]

Dang, girl! That is impressive results my dear. I really like your oncologist - got you out of the woods with the aggressive chemo, but really wants to put you back into a more targeted regime. Just when you were getting used to having no hair - go figure!

Good work, Joy - and I deliberately give you credit.

Now to refresh your memory....it's EMPTY stomach on the Tykerb and it doesn't matter if it's am or pm - it sort of depends on how your body reacts to it.

Flori is I think the expert in tykerb+herceptin. I don't think she progressed on Tykerb previously but I'm sure she will chime in.

There was a presentation at San Antonio in the general session where Jenny Chang looked at the different mechanisms of action in Herceptin and Tykerb. It clearly showed they acted on different pathways. So it made sense why one might work while another didn't, and to me it also explained why there might be synergy between the two, moving towards the closing all doors approach. If resistance develops on one path, ambush it on the other path. I know your oncologist will watch you closely on this.

Thanks for the great news!