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In the new work, a special protein induced hormone receptor–negative breast cancer cells in the lab to produce the receptors and respond to tamoxifen treatment, cancer biologist Caroline Ford of Lund University in Malmö, Sweden, and her colleagues found.
As well as kick-starting hormone receptor production in breast cancer tumors, Wnt-5a can help prevent cancer from spreading. "
I hope this approach can be used to resensitize hormone receptor positive tumors that become resistant to hormonal therapy.
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