http://www.umm.edu/general_surgery/b....htm#Alexander
"Dr. Alexander is recognized for developing innovative techniques to treat patients with advanced cancers of the gastrointestinal tract, especially the liver. One example is
isolated hepatic perfusion, a way to circulate high doses of chemotherapy directly into the liver to treat patients with inoperable cancer. With this "closed loop" technique, only the liver is exposed to the chemotherapy, protecting other organs and minimizing the side effects of treatment."