Bull Exp Biol Med. 2007 Apr;143(4):449-51.
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Soluble fragment of HER2/neu receptor in the serum of patients with breast cancer with different levels of this protein expression in the tumor.
Kushlinskii NE,
Shirokii VP,
Gershtein ES,
Yermilova VD,
Chemeris GY,
Letyagin VP.
N. N. Blokhin National Oncological Research Center, Russian Academy of Medical Sciences, Moscow.
Serum level of soluble HER2/neu in patients with tumors characterized by high expression of this protein (2+/3+ according to immunohistochemical analysis) was significantly higher than in patients with low expression of HER2/neu and in women with benign diseases of the mammary glands. The level of HER2/neu in the serum decreased after removal of the primary tumor in the majority of patients.