Valerie,
The length of time that a patient receives Herceptin is based on staging. If you are stage I or II then the accepted protocol is 1 year anthough some oncologists may prefer the protocol used in the HERA trials - 2 years.
Many patients who are Stage III & IV have been on Herceptin for more than 2 years.
Christine had been on it for almost 9 years. There are really no known long term side effects to Herceptin although some patients may see a gradual decline in their heart's ejection factor. This is usually treated by discontinuing Herceptin for a period of time to enable the ejection factor to bounce back, but this is rare.
At San Antonio, Saturday night they showed a slide of a study that showed that 20% of bc patients change HER2 status. Either from + to - or from - to +. They did not differientiate.
Regards
Joe
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