[dlaxague]

Hi Robin,

I haven't taken these drugs, so can't answer your question. But I have a tag-along question to add to yours.

In the study most recently reported, which was of premenopausal women doing ovarian suppression and Tamoxifen or an AI plus Zometa every 6 months, there was a decrease in all mets by 36%, not just bone (a surprise to almost everyone). In addition, there were no reports of osteonecrosis of the jaw. But that's just one study.

I don't know if there's a relationship between ONJ and bisphosphonate dose, but I would suspect that to be true. There has been a very wide dose range especially when the drugs are given to women with active bone mets. I think that more recently, most oncs have backed off from the more frequent dose interval when administering bisphosphonates.

So when answering Robin's question, would you also say what bisphosphonate and what dose (if known) and how often you take (or took) it?

Debbie Laxague