HER2 Support Group Forums - View Single Post

Nguyen · 10-18-2008, 01:50 PM

Perhaps this would work.

Nguyen

And in another interview (Breast Cancer Update (2005): Clinical experience with fulvestrant), Dr. Charles L Vogel noted that fulvestrant is a very good drug with minimal toxicity, and not much buttock pain even with a five-cc injection, and with less degree of joint discomfort that seen with the aromatase inhibitors, so that it is certainly a viable alternative to aromatase inhibitors in patients who have disease progression on tamoxifen. The pain of the intramuscular site injection can be effectively mitigates either by Emla Cream (lidocaine 2.5% and prilocaine 2.5%) by patch applied one-hour before injection, or somewhat more effectively, by vapocoolant (Fluori-Methane) which unlike Emla Cream is immediate in onset of action and relatively inexpensive (Mawhorter et al., J Travel Med (2004): Topical vapocoolant quickly and effectively reduces vaccine-associated pain: results of a randomized, single-blinded, placebo-controlled study).

10-18-2008, 01:50 PM	#4
Nguyen Senior Member Join Date: Nov 2005 Posts: 530	Perhaps this would work. Nguyen And in another interview (Breast Cancer Update (2005): Clinical experience with fulvestrant), Dr. Charles L Vogel noted that fulvestrant is a very good drug with minimal toxicity, and not much buttock pain even with a five-cc injection, and with less degree of joint discomfort that seen with the aromatase inhibitors, so that it is certainly a viable alternative to aromatase inhibitors in patients who have disease progression on tamoxifen. The pain of the intramuscular site injection can be effectively mitigates either by Emla Cream (lidocaine 2.5% and prilocaine 2.5%) by patch applied one-hour before injection, or somewhat more effectively, by vapocoolant (Fluori-Methane) which unlike Emla Cream is immediate in onset of action and relatively inexpensive (Mawhorter et al., J Travel Med (2004): Topical vapocoolant quickly and effectively reduces vaccine-associated pain: results of a randomized, single-blinded, placebo-controlled study).