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Hi Laurie,
Allergic reactions can develop at any time (even after many exposures without trouble). Once an allergy has developed, it tends to be worse each time the allergen (thing that causes the allergy) is encountered.
I tried to search to see if allergy to Benadryl is common but most the hits were about giving Benadryl FOR an allergy, of course. However, some did discuss true Benadryl allergy, and some said that most were allergic to the additives in the pill but some allergies were to the drug itself. Was your Benadryl oral or IV?
What are you symptoms when you're having this reaction?
I'm sure that they will begin the Herceptin very slowly and be ready to turn it off immediately if you have any reaction. They may even give you some steroids as preventative. The severity of the reaction depends in part upon the dose so even if you do react to the Herceptin it should be mild. Just trying to ease your mind. Let us know how it goes, okay?
Love,
Debbie Laxague
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