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Joan M · 09-18-2008, 07:18 PM

Joy,

I'm sorry that it seems your liver mets are progressing on the trial. I understand how you feel. Last year I had a wedge resection for a solitary pulmonary nodule and I had a "big" idea that I would get something like five years out of it but I got only one year. It was a local recurrence, and I had radiofrequency ablation in mid August. I'm due for my first follow-up scan next week.

I've been only on Herceptin since recurring but will probably be adding Xeloda even if the scan is clear.

Do you have only liver mets? Did you every think of doing RFA? It's done for primary and secondary liver cancer much more frequently than in the lung, and I think in some cases there are really good results for tumors under 3.5 cms.

If anything it could lighten the tumor load which would help make chemo more effective.

It's just a suggestion. I'll keep praying that you will find a good solution.

Joan

09-18-2008, 07:18 PM	#17
Joan M Senior Member Join Date: Oct 2007 Posts: 1,851	Joy, I'm sorry that it seems your liver mets are progressing on the trial. I understand how you feel. Last year I had a wedge resection for a solitary pulmonary nodule and I had a "big" idea that I would get something like five years out of it but I got only one year. It was a local recurrence, and I had radiofrequency ablation in mid August. I'm due for my first follow-up scan next week. I've been only on Herceptin since recurring but will probably be adding Xeloda even if the scan is clear. Do you have only liver mets? Did you every think of doing RFA? It's done for primary and secondary liver cancer much more frequently than in the lung, and I think in some cases there are really good results for tumors under 3.5 cms. If anything it could lighten the tumor load which would help make chemo more effective. It's just a suggestion. I'll keep praying that you will find a good solution. Joan __________________ Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!