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i had neupogen probably a dozen times during my ac and taxotere. the first time was the most excruciating pain i've ever had in my life...all over my body. subsequent shots were not nearly as bad. be prepared with good pain meds (ask onc). mine said tylonel but that would not have touched it in a million years. i've heard that clariten D before shot works wonders but i didn't hear about that till after i had chemo. towards the end of taxotere i had a scary allergic reation to neupogen and had to change to leukine. but i was getting shots several days in a row. i'm only telling you this so that if you have any symptoms that seem extreme to you (like my 103 fever) be sure to call your onc. at once. good luck, gm
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