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I've got stronger words than rats
but I remembered we are in Joe and Christine's living room. So instead, I'll quote my 12 yo niece: That sucks the biggest thumb in the world.
As Becky says, it may be of value to get new biopsy and recheck some of the pathology.
Becky as usual has the ultimate approach to looking at your options (of which there are many, don't forget) but Brenda may be onto something with Abraxane - although I remember BCBS denied that before, it may go through now that Taxol has failed.
Or, taking a break from the taxanes for a while and hit those nodes from another angle (just when they thought they had figured it out)! Like, show them you are WAY sneakier than they are.
I know you have a great team at Rush and will explore what's out there.
The new DM1 trial is beginning to open at some locations, and it's definitely worth checking those out. I'm sure you would be eligible for the new trials (or possibly others that are out there) and then as Dr. Rugo would say "you still have all those chemos" if you are in a study that doesn't do it for you.
Sheila, I'm so sorry you are having to deal with making changes again. I'm wrapping my heart around you right now - can you feel it?
Keep us posted on what you're considering.
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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