Thread: Cox2 and her-2
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Old 08-20-2008, 12:29 PM   #5
fullofbeans
Senior Member
 
Join Date: Jan 2007
Location: UK
Posts: 617
Hi R.B. thanks for your answer but..

1)
"COX 2 products are made on demand as a result of requests received as chemical messengers triggered by a perceived need for inflammatory chemicals "

Do yo know if the demand you refer to above are made ONLY by omega 6 and omega 3 oils ? i.e anything else triggers Cox2 production (chemical messager is the rather vague since all functions in our body are in effect triggered by chemical messages)

2)
"Omega 3 also uses COX2 to make its own products [..]
DHA also block the COX2 Omega 6 production line."

Would it be that omega 3 simply 'goes first' and Cox2 activity for omega6 will resume once the omega3 has been transformed. In which case taking more omega3 is not the answer (for downregulation of Co2x) but in fact limiting omega6 is.

3)
What is the omega3 product transformed into using Cox2? something not inflamatory unlike the omega6?

Many thanks R.B.
__________________

35 y/o
June 06: BC stage I
Grade 3; ER/PR neg
Her-2+++; lumpectomies

Aug 06: Stage IV
liver mets: 6 tumours
July 06 to Jan 07: 2*FEC+6*Taxotere; 3*TACE; LITT
March 07- Sept 07: Vaccination trial (phase 2, peptide based) at the UW (Seattle).
Herceptin since 2006
NED til Oct 09
Recurrence Oct 2009: to internal mammary gland since October 2009 missed on Oct and March 2010 scan.. palpable nodes in May 2010 when I realised..
Nov 2011:7 mets to lungs progressing fast failed hercp/tykerb/xeloda combo..

superior vena cava blocked: stent but face remains puffy

April 2012: Teresa Trial, randomised to TDM1
Nov 2012 progressing on TDM1
Dec 2012 blockage of my airways by tumours, obliteration of these blocking tumours breathing better but hoping for more- at mo too many tumours to count in the lungs and nodes.

Dec 2012 Starting new trial S-222611 phase 1b dual egfr her2+ inhibitor.



'Under no circumstances should you lose hope..' Dalai Lama

Last edited by fullofbeans; 08-20-2008 at 12:32 PM..
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