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If I understand you well R.B one would not need Cox2 inhibitor if they did not eat much omega6 since Cox2 is only activated in the presence of omega6 needed to be converted. Is that really the main activator of Cox2?
You seem to link the final outcome to the production of aromatase, however the BC that are the most statistically affected by healthy life style (junk food full of omega 6) are the BC that are Er-... that said I am sure that there is other pathway as indeed inflamatory response is never good for anyone. (only playing the devil's fat advocate ;-))
Also I want to add to what I posted: maybe tumeric is actually more in use as an anti-angiogenic component in fact as oppose to an Cox2 inhibitor but perhaps performs both function I use to know but forgot..not important just eat the stuff!
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35 y/o
June 06: BC stage I
Grade 3; ER/PR neg
Her-2+++; lumpectomies
Aug 06: Stage IV
liver mets: 6 tumours
July 06 to Jan 07: 2*FEC+6*Taxotere; 3*TACE; LITT
March 07- Sept 07: Vaccination trial (phase 2, peptide based) at the UW (Seattle).
Herceptin since 2006
NED til Oct 09
Recurrence Oct 2009: to internal mammary gland since October 2009 missed on Oct and March 2010 scan.. palpable nodes in May 2010 when I realised..
Nov 2011:7 mets to lungs progressing fast failed hercp/tykerb/xeloda combo..
superior vena cava blocked: stent but face remains puffy
April 2012: Teresa Trial, randomised to TDM1
Nov 2012 progressing on TDM1
Dec 2012 blockage of my airways by tumours, obliteration of these blocking tumours breathing better but hoping for more- at mo too many tumours to count in the lungs and nodes.
Dec 2012 Starting new trial S-222611 phase 1b dual egfr her2+ inhibitor.
'Under no circumstances should you lose hope..' Dalai Lama
Last edited by fullofbeans; 08-20-2008 at 06:03 AM..
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