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Hi Emmay,
I'm sorry your sis is experiencing symptoms from her brain mets and accompaning side effects from her tx's.... If only she could get a break and drop atleast one of these issues!
From the reading I've done, I had thought Avastin was CONTRA-indicated for those with brain mets? I know your sister's onc is really an outside the box person, much to your sisters' advantage.... but still, Avastin can cause bleeding in the brain mets scenario.
Ok, also wanted to report to YOU that I've been on the combo of Xeloda/Temodar in various dosages/schedules for just shy of 3 yrs. Tykerb was added last Oct.
In that time, my current 6-8 brain mets have shrunk, progressed, remained stable and back again, many times. There are three lesions that each measure 1cm now, including one on my pons/brainstem. The remainder are somewhat smaller.
Each time I have to think: what next? as far as treatment goes. Your reports on your sister's experience are a part of that information for me, and I thank you.
Many hugs with good wishes to you both,
pattyz
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