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Becky · 03-18-2008, 05:54 PM

I am not sure if aromatase as it is an enzyme and can be used over and over again. However, biochemically the reactions go

prostaglandin (from the omega 6 pathway)
cholesterol
androgen (need aromatase to convert to)
estrogen

The cholesterol to androgen to estrogen is done in fat cells (which is another reason cholesterol tends to drop when one loses weight as well). This reaction also occurs in the adrenal gland but everyone has them. Its the extra fat cell connection that is more key.

Hopeful - good point on the angiogenesis connection. I didn't even think about that but you are right. The more body tissue one has the more circlulatory system one needs to keep it all alive. Therefore, the quick ability to grow more arteries and veins and have those growth factors (among others that we know and don't know about yet) around and readily available.

03-18-2008, 05:54 PM	#7
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	I am not sure if aromatase as it is an enzyme and can be used over and over again. However, biochemically the reactions go prostaglandin (from the omega 6 pathway) cholesterol androgen (need aromatase to convert to) estrogen The cholesterol to androgen to estrogen is done in fat cells (which is another reason cholesterol tends to drop when one loses weight as well). This reaction also occurs in the adrenal gland but everyone has them. Its the extra fat cell connection that is more key. Hopeful - good point on the angiogenesis connection. I didn't even think about that but you are right. The more body tissue one has the more circlulatory system one needs to keep it all alive. Therefore, the quick ability to grow more arteries and veins and have those growth factors (among others that we know and don't know about yet) around and readily available. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"