HER2 Support Group Forums - View Single Post

Becky · 03-18-2008, 10:06 AM

I believe it all ties in. See the 2 links below that were just in the news today and yesterday.

They are in regard to obesity (more aggressive bc and worse outcome) and exercise (lowers bc risk regardless of family history and whether thin or not).

These show many things. Obesity - more insulin and insulin growth factors in bloodstream, more estrogen in bloodstream, less availability of fat soluble vitamins (like Vitamin D). All the above also increases inflammatory responses.

Exercise (regardless of obesity) - lowers insulin growth factors, regulates insulin, lowers cholesterol (which is a precursor of all sex hormones. LDL (the "bad" cholesterol) increases inflammatory responses in the arteries. Cholesterol's precursor is prostaglandin which does cause inflammation, swelling and pain (the bad pathway of Omega 6 vs the better Omega 3).

I could go on and on but - I won't.

http://www.asco.org/ASCO/News/Cancer...eutersid=10149

http://www.asco.org/ASCO/News/Cancer...eutersid=10142

03-18-2008, 10:06 AM	#4
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	I believe it all ties in. See the 2 links below that were just in the news today and yesterday. They are in regard to obesity (more aggressive bc and worse outcome) and exercise (lowers bc risk regardless of family history and whether thin or not). These show many things. Obesity - more insulin and insulin growth factors in bloodstream, more estrogen in bloodstream, less availability of fat soluble vitamins (like Vitamin D). All the above also increases inflammatory responses. Exercise (regardless of obesity) - lowers insulin growth factors, regulates insulin, lowers cholesterol (which is a precursor of all sex hormones. LDL (the "bad" cholesterol) increases inflammatory responses in the arteries. Cholesterol's precursor is prostaglandin which does cause inflammation, swelling and pain (the bad pathway of Omega 6 vs the better Omega 3). I could go on and on but - I won't. http://www.asco.org/ASCO/News/Cancer...eutersid=10149 http://www.asco.org/ASCO/News/Cancer...eutersid=10142 __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"