|
Remaining on an AI indefinitely is not without risk, as it has been demonstrated that bc can become hypersensitized to a low estrogen environment, and begin growing again, even in the extremely (but not 100%) ER deprived environment created by AI's. The way to "resensitize" the cells to estrogen deprivation is actually counter-intuitive: expose them to high levels of estrogen.
I have read about trials (which I think are going on in the UK only) to see if intermittent use of AI's after 5 years on them (i.e., three months on, three months off) is the way to go to avoid the hypersensitivity issue. At the moment, no one knows what the optimal duration for any of these drugs is.
Hopeful
|