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Katie, you probably already know, one side effect of Tykerb and Xeloda is the diarrhea. Nikki's dosage of Xeloda was 3 pills (1500 mg) in the morning and 4 pills (2000) mg in the evening. She was not on Tykerb and Xeloda at the same time. Her onc. stressed while on the Xeloda that if she had any side effects, like hand and foot syndrome, or diarrhea, to call the office immediately. Xeloda can be adjusted up or down, depending on your tolerance. I know with the Tykerb and Xeloda, it's alot of pills all at once, but maybe if you take a nausea med. beforehand, it may help. My thoughts and prayers are with you. Love, Bill
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