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I am half way through round three of Xeloda and also experiencing hand and foot syndrome/ I moisturize many times a day with Aquaphor, and Burt's Bee products. At first I was massaging but this brings heat to the hands and feet so I stopped. I do soak in cool water and this seems to relieve the hot and painful sensation and I keep my feet up whenever possible. I believe someone suggested B6 and I take it also.
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