Hi Donna, my wife was on Xeloda for several months at 3500 mgs. per day, I think, and suffered no side effects. Her onc. stressed to her repeatedly that if she suffered any side effects, like hand and foot syndrome, or diarrhea, to quit taking the pills and contact her immediately. Don't let your mom try to "tough it out" with diarrhea while on Xeloda if that were to happen. It can lead to renal failure. On the other side of the coin, Xeloda, as others have said, can be increased or decreased according to the tolerance of each person. My thoughts and prayers are with you. Love, Bill
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