HER2 Support Group Forums - View Single Post - I highly recommend viewing for those who are her2+ER+ PR- or+

Lani · 02-27-2008, 12:32 AM

your tumor is more likely to be influenced by the membrane/cytoplasm ER which crosstalks with growth factor receptors. It is less likely to be responsive to tamoxifen unless herceptin and/or iressa or tarceva are given simultaneously ...with AIs expected to work somewhat better as I understand his talk(s) I listened to 2 he gave at the Miami bc conference last week.

Your ER % is higher than most her2+s but others on this site have listed themselves with a similar ER%--I have been told that when ER is looked at with a different technique, rtPCR, that her2+ breast cancers are found to have a lower ER concentration than when looked at with the older techniques.

They are finding out more and more that ER as it has been measured up until now is not the most accurate test.

02-27-2008, 12:32 AM	#10
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	no it does your tumor is more likely to be influenced by the membrane/cytoplasm ER which crosstalks with growth factor receptors. It is less likely to be responsive to tamoxifen unless herceptin and/or iressa or tarceva are given simultaneously ...with AIs expected to work somewhat better as I understand his talk(s) I listened to 2 he gave at the Miami bc conference last week. Your ER % is higher than most her2+s but others on this site have listed themselves with a similar ER%--I have been told that when ER is looked at with a different technique, rtPCR, that her2+ breast cancers are found to have a lower ER concentration than when looked at with the older techniques. They are finding out more and more that ER as it has been measured up until now is not the most accurate test.