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R.B. · 01-03-2008, 05:33 PM

<img src="http://img52.exs.cx/img52/852/mousecheese20gm.gif" alt="Mouse" />Poor little mice. Thanks for clarifying that Andi. May they not die in vain for us.

This is an excellent understandable informative article.

Please discuss dietary changes with your doctor. Fish oil may cause blood thinning and other effects which are an issues for some.

This article may be of interest to your doctor.

RB

http://arthritis-research.com/content/8/1/202

Fish oil: what the prescriber needs to know

Leslie G Cleland email, Michael J James email and Susanna M Proudman email
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, Australia <img src="http://www.comicguide.net/images/smilies/biene.gif" alt="Bee 5" />

"The authors declare the following complementary interests. LGC and MJJ in particular have longstanding research interests in the health benefits of dietary ω3 fats. The Preventive Care Centre of the Royal Adelaide Hospital, under LGCs' direction, distributes fish oil for therapeutic use. SMP directs the Early Arthritis Clinic of the Royal Adelaide Hospital, in which therapeutic effects of fish oil are under evaluation."

"There is a general belief among doctors, in part grounded in experience, that patients with arthritis need nonsteroidal anti-inflammatory drugs (NSAIDs). Implicit in this view is that these patients require the symptomatic relief provided by inhibiting synthesis of nociceptive prostaglandin E2, a downstream product of the enzyme cyclo-oxygenase (COX), which is inhibited by NSAIDs. However, the concept of 'safe' NSAIDs has collapsed following a multiplicity of observations establishing increased risk for cardiovascular events associated with NSAID use, especially but not uniquely with the new COX-2-selective NSAIDs. This mandates greater parsimony in the use of these agents. Fish oils contain a natural inhibitor of COX, reduce reliance on NSAIDs, and reduce cardiovascular risk through multiple mechanisms. Fish oil thus warrants consideration as a component of therapy for arthritis, especially rheumatoid arthritis, in which its symptomatic benefits are well established. A major barrier to the therapeutic use of fish oil in inflammatory diseases is ignorance of its mechanism, range of beneficial effects, safety profile, availability of suitable products, effective dose, latency of effects and instructions for administration. This review provides an evidence-based resource for doctors and patients who may choose to prescribe or take fish oil."

"Safe limits of long chain n3 polyunsaturated fatty acid ingestion"

"A dose of 3 g/day EPA plus DHA has been assessed as safe for general consumption [40]. ....."

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01-03-2008, 05:33 PM	#183
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	<img src="http://img52.exs.cx/img52/852/mousecheese20gm.gif" alt="Mouse" />Poor little mice. Thanks for clarifying that Andi. May they not die in vain for us. This is an excellent understandable informative article. Please discuss dietary changes with your doctor. Fish oil may cause blood thinning and other effects which are an issues for some. This article may be of interest to your doctor. RB http://arthritis-research.com/content/8/1/202 Fish oil: what the prescriber needs to know Leslie G Cleland email, Michael J James email and Susanna M Proudman email Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, Australia <img src="http://www.comicguide.net/images/smilies/biene.gif" alt="Bee 5" /> "The authors declare the following complementary interests. LGC and MJJ in particular have longstanding research interests in the health benefits of dietary ω3 fats. The Preventive Care Centre of the Royal Adelaide Hospital, under LGCs' direction, distributes fish oil for therapeutic use. SMP directs the Early Arthritis Clinic of the Royal Adelaide Hospital, in which therapeutic effects of fish oil are under evaluation." "There is a general belief among doctors, in part grounded in experience, that patients with arthritis need nonsteroidal anti-inflammatory drugs (NSAIDs). Implicit in this view is that these patients require the symptomatic relief provided by inhibiting synthesis of nociceptive prostaglandin E2, a downstream product of the enzyme cyclo-oxygenase (COX), which is inhibited by NSAIDs. However, the concept of 'safe' NSAIDs has collapsed following a multiplicity of observations establishing increased risk for cardiovascular events associated with NSAID use, especially but not uniquely with the new COX-2-selective NSAIDs. This mandates greater parsimony in the use of these agents. Fish oils contain a natural inhibitor of COX, reduce reliance on NSAIDs, and reduce cardiovascular risk through multiple mechanisms. Fish oil thus warrants consideration as a component of therapy for arthritis, especially rheumatoid arthritis, in which its symptomatic benefits are well established. A major barrier to the therapeutic use of fish oil in inflammatory diseases is ignorance of its mechanism, range of beneficial effects, safety profile, availability of suitable products, effective dose, latency of effects and instructions for administration. This review provides an evidence-based resource for doctors and patients who may choose to prescribe or take fish oil." "Safe limits of long chain n3 polyunsaturated fatty acid ingestion" "A dose of 3 g/day EPA plus DHA has been assessed as safe for general consumption [40]. ....." [/SIZE][/SIZE][/SIZE]