Hello,
I was wondering if anyone was able to learn anything regarding the GSK Phase III trial combining Herceptin and Tykerb ( http://clinicaltrials.gov/ct2/show/N...uzumab&rank=10)?
It was a larger study (270) and began in Nov 2005. Clinicaltrials.gov indicates that it is ongoing but not recruiting. Some GSK literature indicated that preliminary results would be available Quarter 3 of 2007.
I know that Nancy Lin at Dana Farber has a current Phase II study (NCT00470704) that started in May of 2007.
And there are a number of others that are new or not yet started that include Herceptin and/or Tykerb plus a Taxol or other agent.
Any insider information would be greatly appreciated.
Regards,
Amy
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Amy age 37 at dx
Feb 2008 Multifocal DCIS
Apr 2008 Bilateral Mastectomies
Sister to Laura age 37 at dx
April 2006
9 cm ER-/PR- Her2 +++/bone mets
neoadjuvant TCH plus Zometa
November 2006
bilateral mastectomy - Change to ER+/PR- Her2 +++
January 2007
innumerable tiny brain mets - WBR
March 2007
good response to WBR - some gone, all smaller
currently on Lapatinib and Xeloda
Feb 2008
Brain MRI: brain mets went from innumerable (jan '07) to 5 (june '07) to 3 (oct '07) to 1 that is getting less conspicuous(feb '08) PET/CT: Slight uptake in some sclerotic bone mets
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