HER2 Support Group Forums - View Single Post - Celecoxib blocks morphine-induced tumor growth in mice

donocco5w4 · 12-28-2007, 02:47 AM

Its not so much that Morphine stimulates tumour growth, but the bodies natural opiates, the Endorphins can act as immunosuppressants and stimulate tumour growth. Both the action of Morphine and the Endorphins can be blocked by the opiate blocker Naltrexone.

There was an experiment where tumour growth could be stimulated when tumour bearing mice were exposed to very stressful situations. The tumour stimulating effect of the stress (in this experiment) could be blocked by Naltrexone. it was presumed that the stress stimulated the mice Endorphin system (to counteract the stress) and the endorphins stimulated tumour growth by acting as an immunosuppressant.

Paul (Pharmacist)

12-28-2007, 02:47 AM	#3
donocco5w4 Member Join Date: Nov 2007 Location: Southern California Posts: 15	Morphine and tumour growth Its not so much that Morphine stimulates tumour growth, but the bodies natural opiates, the Endorphins can act as immunosuppressants and stimulate tumour growth. Both the action of Morphine and the Endorphins can be blocked by the opiate blocker Naltrexone. There was an experiment where tumour growth could be stimulated when tumour bearing mice were exposed to very stressful situations. The tumour stimulating effect of the stress (in this experiment) could be blocked by Naltrexone. it was presumed that the stress stimulated the mice Endorphin system (to counteract the stress) and the endorphins stimulated tumour growth by acting as an immunosuppressant. Paul (Pharmacist)