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One of the toughest things is knowing when to say "it's enough". I know. I took care of my Mom last year, when she was very ill, and I was in charge of her medical care.
I let Mom decide when she'd had enough, and like your Mom, she wasn't ready to give up and fought long and hard. There did come a point when she said it was enough, though. She told me she didn't want to live like that, and she passed a few days later.
Hopefully, your Mom will be able to let you and her doctors know how far she wants you to go, in her care.
It sounds like your Onc has gone above and beyond what most doctors would do. My Mom was lucky enough to have a very caring doctor that went as far as my Mom wanted to go, and didn't give up on her, either.
I think the main thing is to keep her as comfortable as possible, and be there for her.
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