Reduced BRAC1 increases aromatase products.
It looks as if BRAC 1 may act as an aromatase inhibitor (and when BRAC1 mutates does it stop doing that ? - this seems to be the question being asked between the lines)
BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells.
Lu M, Chen D, Lin Z, Reierstad S, Trauernicht AM, Boyer TG, Bulun SE.
http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
"CONCLUSIONS: Selective inhibition of aromatase expression by BRCA1 binding to the I.3/II tumorigenic promoter region may be an important protective mechanism against breast cancer development."