HER2 Support Group Forums - View Single Post - Alcohol increases breast cancer risk by 10% and 40%

R.B. · 10-13-2007, 04:00 AM

Here is a trial in the lab again suggesting differences in effect for different BC status.

http://www.ncbi.nlm.nih.gov/sites/en...t=AbstractPlus

"Treatment of ER+ human breast cancer cells (MCF-7 and ZR75.1) with ethanol at concentrations between 10 and 100 mM was associated with increased cell numbers compared to controls. The ERalpha content and the amount of intracellular cAMP also increased in ER+ cells exposed to ethanol, compared to controls. On the other hand, ethanol treatment did not increase cell proliferation or cAMP levels in the ER- (BT-20 and MDA-MB-231) human breast cancer cells. Therefore, ethanol added at physiologically relevant concentrations to ER+ human breast cancer cell cultures can enhance cell proliferation and increase the content of ERalpha."

10-13-2007, 04:00 AM	#9
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Here is a trial in the lab again suggesting differences in effect for different BC status. http://www.ncbi.nlm.nih.gov/sites/en...t=AbstractPlus "Treatment of ER+ human breast cancer cells (MCF-7 and ZR75.1) with ethanol at concentrations between 10 and 100 mM was associated with increased cell numbers compared to controls. The ERalpha content and the amount of intracellular cAMP also increased in ER+ cells exposed to ethanol, compared to controls. On the other hand, ethanol treatment did not increase cell proliferation or cAMP levels in the ER- (BT-20 and MDA-MB-231) human breast cancer cells. Therefore, ethanol added at physiologically relevant concentrations to ER+ human breast cancer cell cultures can enhance cell proliferation and increase the content of ERalpha."