HER2 Support Group Forums - View Single Post - loss of a single (of two copies) of a tumor suppressor gene enough to flip bc "switch

Lani · 09-04-2007, 06:43 AM

responsible for her2+ bc (it may not be the only one) and it was Xlinked so that only one copy was necessary to cause the disease. They same gene is necessary for T regulatory cells (the ones which help her2+ breast cancer hide from the immune system) Interestingly, this gene seemed especially linked to her2+ ER+ breast cancer, a group of breast cancers (probably several when it all comes down to it) for which they are having a hard time designating a molecular subtype of bc --as best I can ascertain ~30% of luminal Bs are her2+ ER+. The gene is called FOXP3 and its absence allows
amplification of her2. Use the search funciton and put in FOXP3 if you missed my earlier post.

Hope this helps...

09-04-2007, 06:43 AM	#6
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	In early summer I posted a gene they found which appeared responsible for her2+ bc (it may not be the only one) and it was Xlinked so that only one copy was necessary to cause the disease. They same gene is necessary for T regulatory cells (the ones which help her2+ breast cancer hide from the immune system) Interestingly, this gene seemed especially linked to her2+ ER+ breast cancer, a group of breast cancers (probably several when it all comes down to it) for which they are having a hard time designating a molecular subtype of bc --as best I can ascertain ~30% of luminal Bs are her2+ ER+. The gene is called FOXP3 and its absence allows amplification of her2. Use the search funciton and put in FOXP3 if you missed my earlier post. Hope this helps...