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chrisy · 08-26-2007, 12:14 PM

Hi Irene,

I am, as you know, in the same Tykerb/Avastin trial Ellen mentioned. It's been an easy combo with only some bp issues that for me have been easily managed. The trials are at UCSF and MSK only, I think.
At 6 weeks and at 12 weeks, scans have shown "stable" for me on this combo. So it has worked in terms of shutting down the growth. I'd of course rather see some disappearing acts and have not given up on that yet.

Research on Avastin indicates that it has not had good success as single agent, but has had fabulous results in combination with chemo's especially as first-line in the metastatic setting. Nonethless, I think this is a viable option for you to try even though you've had a lot of treatment. There are also other trials with Avastin.

Good luck, warrior gal! Keep us posted on what you decide.

08-26-2007, 12:14 PM	#12
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Hi Irene, I am, as you know, in the same Tykerb/Avastin trial Ellen mentioned. It's been an easy combo with only some bp issues that for me have been easily managed. The trials are at UCSF and MSK only, I think. At 6 weeks and at 12 weeks, scans have shown "stable" for me on this combo. So it has worked in terms of shutting down the growth. I'd of course rather see some disappearing acts and have not given up on that yet. Research on Avastin indicates that it has not had good success as single agent, but has had fabulous results in combination with chemo's especially as first-line in the metastatic setting. Nonethless, I think this is a viable option for you to try even though you've had a lot of treatment. There are also other trials with Avastin. Good luck, warrior gal! Keep us posted on what you decide. __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure