Apparently, Epsolin also makes a difference. Decadron can usually continue, but they take the Tykerb dose up. The logic has been that Epsolin (Dilantin) and Dec metabolizes the Tykerb faster... hence the dosage adjustment. Mom's been on small amounts of Dec (0.5mg - 1mg) for the last 6 months while taking Tykerb + Xeloda.
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