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heblaj01 · 04-06-2007, 06:38 PM

Most of the recommandations (treatment,diet...) seem to make sense in the CAAT web site (except perhaps the use of fructose).
What is lacking are direct references to the publications of clinical trial reports.
For instance I could not reach any paper on one of the researchers called Lorincz. May be that research was taking place before the computer era.
I also failed to find any interesting message board report of the use of CAAT, although I must recognize it is impossible to be exhaustive in such a web search.

The only easily accessible small piece of factual info is this 2000 report I found in Life Extension regarding a small trial:

http://www.lef.org/whatshot/2000_10.html#caat (extract)

Controlled amino acid treatment fights cancer

Acting upon the knowledge that cancer needs specific amino acids to be able to survive, the A P John Institute for Cancer Research has formulated what it calls Controlled Amino Acid Treatment, or CAAT, to aid in the battle against cancer. In a study conducted to confirm earlier research which indicated that amino acid deprivation may be of benefit in cancer, nineteen patients with inoperable or highly metastatic cancer of the breast, lung, colon, brain, pancreas, ovaries who were given six months to live by their physicians were given CAAT along with conventional therapy. Three of the patients were treated with CAAT only. CAAT consists of an amino acid supplement in which certain amino acids necessary for cancer growth are eliminated, a low calorie, low carbohydrate diet rich in omega-3 fatty acids, and supplementation with the following: N-acetylcysteine, tocotrienols, genistein, calcium D-glucarate, L-carnitine and coenzyme Q10, plus an antioxidant formula if their cancer was slow growing. Those with faster growing cancers were advised against antioxidant supplementation because of the concern that it might inhibit apoptosis (cell death). (Tocotrienols should be excluded in patients with non-Hodgkin's lymphoma.)

All nineteen patients outlived their estimated remaining six months, and sixteen are still alive an average of four years later, with fifteen experiencing a reduction in tumor size or elimination of the cancer. Two who took CAAT alone without conventional therapy have been in remission for over six years. Two of the patients who did not survive nonetheless experienced a reduction in tumor size.

CAAT's diet may work partly on the same principle as calorie restriction, as an anticancer effect has been observed in animals placed on a calorie restricted diet. The intent of CAAT is to inhibit the formation of elastin needed for angiogenesis; impair glycolysis, thereby helping to starve the cancer cells, and to inhibit cancer cells' ability to manufacture DNA and various growth factors.

October 10, 2000

So it is difficult to come to a conclusion on the merits of CAAT.

04-06-2007, 06:38 PM	#7
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	Most of the recommandations (treatment,diet...) seem to make sense in the CAAT web site (except perhaps the use of fructose). What is lacking are direct references to the publications of clinical trial reports. For instance I could not reach any paper on one of the researchers called Lorincz. May be that research was taking place before the computer era. I also failed to find any interesting message board report of the use of CAAT, although I must recognize it is impossible to be exhaustive in such a web search. The only easily accessible small piece of factual info is this 2000 report I found in Life Extension regarding a small trial: http://www.lef.org/whatshot/2000_10.html#caat (extract) Controlled amino acid treatment fights cancer Acting upon the knowledge that cancer needs specific amino acids to be able to survive, the A P John Institute for Cancer Research has formulated what it calls Controlled Amino Acid Treatment, or CAAT, to aid in the battle against cancer. In a study conducted to confirm earlier research which indicated that amino acid deprivation may be of benefit in cancer, nineteen patients with inoperable or highly metastatic cancer of the breast, lung, colon, brain, pancreas, ovaries who were given six months to live by their physicians were given CAAT along with conventional therapy. Three of the patients were treated with CAAT only. CAAT consists of an amino acid supplement in which certain amino acids necessary for cancer growth are eliminated, a low calorie, low carbohydrate diet rich in omega-3 fatty acids, and supplementation with the following: N-acetylcysteine, tocotrienols, genistein, calcium D-glucarate, L-carnitine and coenzyme Q10, plus an antioxidant formula if their cancer was slow growing. Those with faster growing cancers were advised against antioxidant supplementation because of the concern that it might inhibit apoptosis (cell death). (Tocotrienols should be excluded in patients with non-Hodgkin's lymphoma.) All nineteen patients outlived their estimated remaining six months, and sixteen are still alive an average of four years later, with fifteen experiencing a reduction in tumor size or elimination of the cancer. Two who took CAAT alone without conventional therapy have been in remission for over six years. Two of the patients who did not survive nonetheless experienced a reduction in tumor size. CAAT's diet may work partly on the same principle as calorie restriction, as an anticancer effect has been observed in animals placed on a calorie restricted diet. The intent of CAAT is to inhibit the formation of elastin needed for angiogenesis; impair glycolysis, thereby helping to starve the cancer cells, and to inhibit cancer cells' ability to manufacture DNA and various growth factors. October 10, 2000 So it is difficult to come to a conclusion on the merits of CAAT.