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I have been wondering about the use of Tykerb & Herceptin, also. I just completed my 6th Taxotere & Herceptin (1x/3weeks) and while I have tolerated it well and it has gotten me very close to NED I seem to be having more difficulty with it as I go. I didn't respond to Herceptin alone. My onc wants to discuss next treatment option as he isn't comfy w/ a med holiday yet. My initial thought was to save Tykerb for later, my husband says why wait? The fact that Tykerb is small molecule and can get in those microscopic cells easier does make me think I should try Tykerb next. Any other thoughts on this is appreciated.
Thanks!
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Liz
3/05 Initial dx invasive dc 2 cm lump, age 39
lumpectomy & 3 of 5 nodes +, ER+/PR+, Her2+++
alternative chemo 5/05-7/05, rad 8/05-10/05
7/06 dx mets to vertebrae, pelvis & chest lymph nodes
8/06 - 10/06 tamoxifen, herceptin, oophorectomy & zometa
11/06 PET/CT showed continued bone mets, new spot on liver
12/06 began taxotere/herceptin 1x/3 weeks,
2/07 - 2-08 NED!
3/08 progression, start taxol/herceptin weekly, monthly zometa
8/08 start ai & herceptin
12/08 - progression, start weekly navelbine/herceptin thru 6/09 & monthly zometa
7/09 - PET/CT showed improvement in spine, but 2-3 lymph nodes in chest became active
9/09 - 11/09 - weekly abraxane/herceptin
12/09 - PET/CT - chest lymph nodes resolved, progression in spine & pelvis
2/10 - 6/10 - start tykerb/xeloda, progession in spine & pelvis
7/10 - start taxotere/carboplatin/herceptin
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