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Becky · 03-16-2007, 08:29 AM

Val (and others)

There is a clinical trial with Tykerb and Herceptin but there is absolutely no data yet.

There have been no studies using Tykerb alone but then again, there have been no trials using Herceptin alone either. In the metastatic setting comparing Herceptin/Xeloda versus the Tykerb/Xeloda - Herceptin/Xeloda outperformed Tykerb BUTTTT, Herceptin does nothing in regard to reducing and preventing recurrence of brain mets. Therefore, if one is Stage 4 and has had brain mets, there is good science behind the switch to Tykerb. If Herceptin is working and one is NED and has never had brain mets (and it were me), I might leave well enough alone and save the drug if I should need it later.

03-16-2007, 08:29 AM	#6
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Val (and others) There is a clinical trial with Tykerb and Herceptin but there is absolutely no data yet. There have been no studies using Tykerb alone but then again, there have been no trials using Herceptin alone either. In the metastatic setting comparing Herceptin/Xeloda versus the Tykerb/Xeloda - Herceptin/Xeloda outperformed Tykerb BUTTTT, Herceptin does nothing in regard to reducing and preventing recurrence of brain mets. Therefore, if one is Stage 4 and has had brain mets, there is good science behind the switch to Tykerb. If Herceptin is working and one is NED and has never had brain mets (and it were me), I might leave well enough alone and save the drug if I should need it later. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"