HER2 Support Group Forums - View Single Post - benefit of fruits/veges in diet may vary by breast cancer type--er+ vs ER-

Lani · 02-24-2007, 04:41 AM

and perhaps simiilarly by her2+ vs her2-(?)--as usual, have not found (yet) evidence it has been looked at:

Breast Cancer Res Treat. 2007 Feb 21; [Epub ahead of print]
Intake of fruits, and vegetables in relation to breast cancer risk by hormone receptor status.

Lissowska J,
Gaudet MM,
Brinton LA,
Peplonska B,
Sherman M,
Szeszenia-Dabrowska N,
Zatonski W,
Garcia-Closas M.
Department of Cancer Epidemiology and Prevention, Cancer Center and M. Sklodowska-Curie Institute of Oncology, WK Roentgena 5, 02-781, Warsaw, Poland.
The inconsistent associations between fruit and vegetable intake and breast cancer risk may be due to heterogeneity of associations by estrogen (ER) and progesterone receptor (PR) status of the tumors. We evaluated this hypothesis in a large (2,386 cases and 2,503 controls) population-based case-control study in Poland, conducted between 2000 and 2003. We observed significant associations between reduced overall risk of breast cancer and increasing levels of total fruit intake (odds ratio (OR) for highest versus lowest quartile = 0.76, 95%CI = 0.63-0.91; p-trend = 0.01), but not for total vegetable intake (1.13 (0.93-1.37), p-trend = 0.25), after controlling for age, energy intake and known risk factors for breast cancer. The inverse association with total fruit intake was stronger for risk of ER+ (0.69 (0.54-0.88), p-trend = 0.01) than ER- tumors (0.89 (0.67-1.19), p-trend = 0.57) (p-heterogeneity = 0.02). In conclusion, this study suggests that fruit intake might have differential associations for breast tumor subtypes defined by ER status.
PMID: 17318377 [PubMed - as supplied by publisher]

02-24-2007, 04:41 AM	#1
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	benefit of fruits/veges in diet may vary by breast cancer type--er+ vs ER- and perhaps simiilarly by her2+ vs her2-(?)--as usual, have not found (yet) evidence it has been looked at: Breast Cancer Res Treat. 2007 Feb 21; [Epub ahead of print] Intake of fruits, and vegetables in relation to breast cancer risk by hormone receptor status. Lissowska J, Gaudet MM, Brinton LA, Peplonska B, Sherman M, Szeszenia-Dabrowska N, Zatonski W, Garcia-Closas M. Department of Cancer Epidemiology and Prevention, Cancer Center and M. Sklodowska-Curie Institute of Oncology, WK Roentgena 5, 02-781, Warsaw, Poland. The inconsistent associations between fruit and vegetable intake and breast cancer risk may be due to heterogeneity of associations by estrogen (ER) and progesterone receptor (PR) status of the tumors. We evaluated this hypothesis in a large (2,386 cases and 2,503 controls) population-based case-control study in Poland, conducted between 2000 and 2003. We observed significant associations between reduced overall risk of breast cancer and increasing levels of total fruit intake (odds ratio (OR) for highest versus lowest quartile = 0.76, 95%CI = 0.63-0.91; p-trend = 0.01), but not for total vegetable intake (1.13 (0.93-1.37), p-trend = 0.25), after controlling for age, energy intake and known risk factors for breast cancer. The inverse association with total fruit intake was stronger for risk of ER+ (0.69 (0.54-0.88), p-trend = 0.01) than ER- tumors (0.89 (0.67-1.19), p-trend = 0.57) (p-heterogeneity = 0.02). In conclusion, this study suggests that fruit intake might have differential associations for breast tumor subtypes defined by ER status. PMID: 17318377 [PubMed - as supplied by publisher]