HER2 Support Group Forums - View Single Post - for those with metastatic brst cancer deciding on whether to remove primary tumor

heblaj01 · 12-24-2006, 08:29 PM

The abstract is now available on Pubmed at:
http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract

The study results indicate that the benefit of primary excision in metastatic breast cancer is only apparent when the only mets are bone mets.

I remember that a few years ago some oncs were hesitant to excise (not only because they thought it would not change the outcome as noted in the study) but also due to the observation that while primary tumors initiate local growth factors they also appear to generate antiangiogenesis agents acting remotely whose effect may be to slow the spread of mets.
I don't know if this theory has been confirmed later on.

12-24-2006, 08:29 PM	#2
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	The abstract is now available on Pubmed at: http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract The study results indicate that the benefit of primary excision in metastatic breast cancer is only apparent when the only mets are bone mets. I remember that a few years ago some oncs were hesitant to excise (not only because they thought it would not change the outcome as noted in the study) but also due to the observation that while primary tumors initiate local growth factors they also appear to generate antiangiogenesis agents acting remotely whose effect may be to slow the spread of mets. I don't know if this theory has been confirmed later on.