HER2 Support Group Forums - View Single Post - velcade(already FDA approved) and Herceptin synergistic --trial starting

heblaj01 · 12-09-2006, 11:03 AM

Lani,
Can you clarify a point I do not understand even after reading the full text of the research paper (http://mct.aacrjournals.org/cgi/rapi...-06-0104v1.pdf).

Did the researchers prove that they overcame Herceptin resistance in the in vitro tests?
The reason I am not sure is that while they mention that one of the aim of the study was resistance, there is no clear indication that they used already resistant cancer cells. They appear to have selected low enough concentrations of Velcade & Herceptin to make them ineffective as single agents in treating the cells & then showed that combining the two low concentration drugs they achieved effective treatment.
Is that a correct understanding?

12-09-2006, 11:03 AM	#2
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	Lani, Can you clarify a point I do not understand even after reading the full text of the research paper (http://mct.aacrjournals.org/cgi/rapi...-06-0104v1.pdf). Did the researchers prove that they overcame Herceptin resistance in the in vitro tests? The reason I am not sure is that while they mention that one of the aim of the study was resistance, there is no clear indication that they used already resistant cancer cells. They appear to have selected low enough concentrations of Velcade & Herceptin to make them ineffective as single agents in treating the cells & then showed that combining the two low concentration drugs they achieved effective treatment. Is that a correct understanding?