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Cindy, I was 39 at initial dx and refused tamoxifen coz I didn't want to mess around w/ my hormones any more than necessary. Plus, from what I read at the time, after 5 years on tamoxifen it can start to act like estrogen, that's why they take you off it. Now at 41, with mets dx, I tried tamoxifen before getting my ovaries out, have not had a response, so went off it. The plan is to get mets stable, then try an AI. I was worried about getting ovaries out since I was still regular, etc. but have to say I'm very happy it's not been a big issue and don't regret having it done even though haven't responded yet. Good luck!
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Liz
3/05 Initial dx invasive dc 2 cm lump, age 39
lumpectomy & 3 of 5 nodes +, ER+/PR+, Her2+++
alternative chemo 5/05-7/05, rad 8/05-10/05
7/06 dx mets to vertebrae, pelvis & chest lymph nodes
8/06 - 10/06 tamoxifen, herceptin, oophorectomy & zometa
11/06 PET/CT showed continued bone mets, new spot on liver
12/06 began taxotere/herceptin 1x/3 weeks,
2/07 - 2-08 NED!
3/08 progression, start taxol/herceptin weekly, monthly zometa
8/08 start ai & herceptin
12/08 - progression, start weekly navelbine/herceptin thru 6/09 & monthly zometa
7/09 - PET/CT showed improvement in spine, but 2-3 lymph nodes in chest became active
9/09 - 11/09 - weekly abraxane/herceptin
12/09 - PET/CT - chest lymph nodes resolved, progression in spine & pelvis
2/10 - 6/10 - start tykerb/xeloda, progession in spine & pelvis
7/10 - start taxotere/carboplatin/herceptin
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