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An other process taking place when antiangiogenesis drugs are used may influence the activities of VDA's. I am refering to research (mainly by Dr R. Jain) showing that in the initial phase of the mode of action of antiangiogenesis drugs some new capillaries are damaged but others feeding tumours are "repaired" making them less leaky & temporarily reducing the internal pressure in tumours. This decrease allows a "window of opportunity" for anticancer drugs to more easily penetrate the tumours.
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