and in premenopausal women only--
They may increase the chance of ER+ breast cancer
Double-edged sword, it seems!
Dietary lignan intakes and risk of breast cancer by tumor estrogen receptor status
Journal Breast Cancer Research and Treatment
Publisher Springer Netherlands
ISSN 0167-6806 (Print) 1573-7217 (Online)
Subject Medicine
Issue Volume 99, Number 3 / October, 2006
Category Epidemiology
DOI 10.1007/s10549-006-9196-x
Pages 309-311
Online Date Thursday, March 16, 2006
Susan E. McCann1, 5 , Swati Kulkarni2, Maurizio Trevisan3, Dominica Vito3, Jing Nie3, Stephen B. Edge2, Paola Muti4 and Jo L. Freudenheim3
(1) Department of Epidemiology, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY, USA
(2) Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA
(3) Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY, USA
(4) Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy
(5) Department of Epidemiology, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY, USA
Received: 3 February 2006 Accepted: 7 February 2006 Published online: 16 March 2006
Abstract We examined the association of dietary lignan intake with estrogen receptor negative (ER?) and ER positive (ER+) breast cancer risk in a breast cancer case–control study. Among premenopausal women only, there was a reduced risk of ER? breast cancer for those in the highest compared to the lowest quartile of lignan intake suggesting that the observed negative association of lignans with breast cancer may be limited to ER? tumors.
Keywords breast cancer - estrogen receptor - lignans - phytoestrogens
Susan E. McCann
Email:
susan.mccann@roswellpark.org
Phone: +1-(716)-845-8842
Fax: +1-(716)-845-8487