Sandy-
I got occasional diarheara on the xeloda alone, usually controlled with immodum, and for me it got a bit worse once the tykerb was added - i generally have it once in the morning, and then hopefully that's it...
also, i recall that the 1st few days after taking tykerb, the fatigue hit me really hard! but it settled down somewhat and i got back to my usual schedule.
i never lost my appetite with this combo, (darn!), so hopefully once the fatigue passes you'll feel a bit more like eating.
Good luck with things,
Shell
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