HER2 Support Group Forums - View Single Post - are you ready for something completely different? It may be progesterone,not estrogen

Joy · 09-07-2006, 08:17 AM

Thanks Lani, I was very interested to read this (not that I'm smart enough to get all of it). If I'm interpreting this right, then this is very relevant for me personally (although that is a big 'IF'). When I switched from Taxol/Carbo cause it plateaued in efficacy to Megace (progesterone) my liver lesions tripled and doubled in 6 weeks time and I'm wondering if there is a connection between that and this article's info. In the past estrogen manipulating treatments have worked REALLY well for me. We thought that Megace would work well too. I could be really wrong, but it just seems crazy that I had SO much progression while on a progestriogenic drug. Do you have any thoughts?

By the way I love all of your articles and insights. I just hope that YOU are doing well and feeling great, cause we are here for you, too.

09-07-2006, 08:17 AM	#2
Joy Senior Member Join Date: Jul 2005 Location: Ft. Collins, Colorado Posts: 546	this is fascinating Thanks Lani, I was very interested to read this (not that I'm smart enough to get all of it). If I'm interpreting this right, then this is very relevant for me personally (although that is a big 'IF'). When I switched from Taxol/Carbo cause it plateaued in efficacy to Megace (progesterone) my liver lesions tripled and doubled in 6 weeks time and I'm wondering if there is a connection between that and this article's info. In the past estrogen manipulating treatments have worked REALLY well for me. We thought that Megace would work well too. I could be really wrong, but it just seems crazy that I had SO much progression while on a progestriogenic drug. Do you have any thoughts? By the way I love all of your articles and insights. I just hope that YOU are doing well and feeling great, cause we are here for you, too. __________________ with love and gratitude, joy dx stage I 2/2000er/pr+; her- per IHClumpectomy4 rounds A/C30 radstamoxifendx stage 4 5/2002huge mets to livertiny mets to lungsstopped tamoxifen5/02 taxotere/xeloda*her 2 checked with FiSH-her2+++herceptin 2/03 stopped chemo femara w/herceptinzolodex04 switched to aromasin w/herceptin05 high estrogen tx11/05taxol/carbo7/06 stopped chemo; megace/herceptin*9/06navelbine/herceptin5/07tykerb/xeloda great response4/08 progression in liver; ooph/ faslodex /herceptin 6/08 began Herceptin DM-1 9/08 progression