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chrisy · 08-30-2006, 01:45 PM

good question...maybe somebody can track this down.

I have not seen these statistics, only references to "poor prognosis" but I think the real challenge is that the game has really changed with Herceptin and now, hopefully, Tykerb. Any statistics you see that are older than a few years ago for metastatic disease do not reflect the improvement in survival due to Herceptin.

Statistics for early stage Her2 are now absolutely invalid as adjuvant Herceptin has only been approved in the past year.

So I guess I'm saying, use caution with any survival stats you may find - if they are for the general Her2 population, they probably look far worse than the true picture is today. Stats for Herceptin or Tykerb trials may give a more accurate picture, but these would also be skewed.

Here's to blowing away ALL the "bad stats" and creating new positive ones!

08-30-2006, 01:45 PM	#2
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	good question...maybe somebody can track this down. I have not seen these statistics, only references to "poor prognosis" but I think the real challenge is that the game has really changed with Herceptin and now, hopefully, Tykerb. Any statistics you see that are older than a few years ago for metastatic disease do not reflect the improvement in survival due to Herceptin. Statistics for early stage Her2 are now absolutely invalid as adjuvant Herceptin has only been approved in the past year. So I guess I'm saying, use caution with any survival stats you may find - if they are for the general Her2 population, they probably look far worse than the true picture is today. Stats for Herceptin or Tykerb trials may give a more accurate picture, but these would also be skewed. Here's to blowing away ALL the "bad stats" and creating new positive ones! __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure