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I've been using melatonin for years as a sleep aid. I looked at my CBC reports for this spring/summer while on Navelbine/Herceptin and now Xeloda/Herceptin, and I can report that my platelet counts have remained in the high normal range. Don't know if this is related to melatonin use. I'm also on low-dose aspirin therapy to keep fibrin sheaths from developing around my port catheter and my platelet counts don't seem to suffer from this.
I'd be careful about self-dosing with melatonin or any supplement while on chemo; I always check with my onc before adding anything new.
<3 Lolly
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